By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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Additional resources for Advances in Cancer Research, Vol. 15
Other SV40-transformed cell lines contained 2-5 DNA equivalentsjcell. Although the estimates vary, these reports, plus an additional one (Tai and O’Brien, 1969), all indicated that there were apparently multiple copies of the SV40 genome per transformed cell. , 1971). , 1964) in spite of trials in many laboratories. What, then, is the state of these multiple copies of viral nucleic acid within the transformed cells? , 1968) established the following points about the physical state of the viral DNA: ( a ) It is in the nucleus; no hybridizable DNA was detected in cytoplasmic extracts.
The agglutination reaction could be inhibited with N-acetylglucosamine. Agglutination of transformed cells by Concanavalin A has been reported by Inbar and Sachs (1969). Normal cells were agglutinated only after mild trypsinization, again suggesting the cryptic nature of the agglutination sites on normal cells. The authors claimed that the sites were specifically exposed during viral transformation. , 1970). Of interest is thc report (Benjamin and Burger, 1970) that the change in tlic cell membrane which renders a cell agglutinable by Concanavalin A was not detected after infection with mutants of polyoma virus previously denionstrated to be defective in their ability to transform cells.
1970) demonstrated that lung cells derived from hybrid animals originating from a cross of the Syrian and Rumanian species of hamsters did develop Tantigen when transformed by SV40. In contrast, after exposure to SV40, lung cells from Syrian hamsters frequently acquire the property of unlimited growth in vitro but do not develop detectable levels of T-antigen (Diamandopoulos and Enders, 1965; van der Noordaa and Enders, 1966; Nachtigal and Butel, 1970). , 1965). , 1965) and 70,000TABLE I1 COMPARISON OF PROPERTIES OF HAMSTER TUMORCELLLINESCONTAINING SV40 TUMORANTIQEN IN EITHER THE NUCLEUS OR T m CYTOPLASM OF CELLS Propertya Contain nuclear SV40 T-antigen by IF Contain cytoplasmic SV40 T-antigen by IF Contain SV40 T-antigen by CF Contain SV40 S-antigen by IF Stable nuclear localization of T-antigen Stable cytoplasmic localization of T-antigen Indefinite life-span in vitro Readily transplantable in vivo Elicit SV40 T-antibody in vivo Induce SV40 transplantation immunity (immunogenic) Rejected by SV40 or PARA-immune animals (immunosensitive ) 0 T = Nuclear T-positive cell line Cytoplasmic T-positive cell line + 0 + ++ 0 + + + + + + + + 0 + + + + + + 0 tumor; S = surface; IF = immunofluorescence; CF = complement fixation.