By Gerald Schochetman (auth.), Gerald Schochetman Ph.D., J. Richard George Ph.D. (eds.)
Given the continued excessive point of shock between well-being execs and most people approximately matters concerning AIDS, this quantity on trying out for AIDS and similar viruses is intensely well timed. The booklet has been written through specialists within the zone of AIDS trying out, lots of whom are on the facilities for sickness keep watch over. The publication contains numerous chapters which evaluate the various laboratory checks on hand for detecting the AIDS virus (HIV). It additionally addresses such themes as moral issues in AIDS trying out, HIV an infection in youngsters, checking out for different human viruses on the topic of HIV, security practices in HIV-testing laboratories, and dealing with occupational publicity to HIV. The e-book is meant for public overall healthiness officers interested by HIV checking out, health center directors and medical laboratory administrators answerable for constructing HIV trying out courses, and physicians involved in trying out for AIDS.
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Additional info for AIDS Testing: Methodology and Management Issues
Massive budding of virus from the membrane results in cell lysis. Massive viral replication commandeers cellular transcriptional/translational machinery required for maintenance of cellular integrity. Viral infcction somehow initiates normal cellular processes that result in terminal differentiation and senescence, the so-called programmed cell death that is associated with DNA fragmentation (apotosis). Both in vitro studies and clinical studies support the notion that increased viral replication is associated with more rapid CD4 T-cell depletion, which in turn may be determined by the activation state of the infected cells.
Acad Sci USA 1987;84: 4601-4605. 24. Weinhold KJ, Lyerly HK, Matthews TJ, Tyler DS, Ahearne PM, Stine KC, Langlois AJ, Durack DT, Bolognesi DP. Cellular anti-gp120 cytolytic reactivities in HIV-1 seropositive individuals. Lancet 1988;i:902-905. 25. Siciliano RF, Lawton T, Knall C, Karr RW, Berman P, Gregory T, Reinherz EL. Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4 + cell depletion. Cell 1988;54:561-575. 26.
Antigen-MHC recognition is performed by the TCR, which recognizes antigen bound in a pocket of the MHC molecule. Most nucleated cells express class I molecules and can present antigen to or be recognized by CD8 T cells. MHC class II has a more limited cellular distribution, being confined to cells of monocyte lineage and B cells. The latter are very potent APC for CD4 T cells (a particularly potent combination is B cells and CD4 T cells specific for different epitopes on the same antigen). Some cell types that normally do not express MHC class II do so when activated (T cells) or stimulated by an inflammatory response (epithelial cells).